Lipid nanoparticles (LNPs) are a class of nanoparticles that are used for drug delivery. As the name suggests, these couriers are nano-sized particles that are composed of lipids. They are porous spheres composed of various types of lipids that encapsulate therapeutics and vaccines. The size of LNPs can range from 10 to 1000 nm with the diameter being inversely proportional to their hydrophobicity. The surface area to volume ratio of these nanoparticles is very high and this allows them to carry many different types of components.
The first attempts to use these particles as drug delivery carriers were described in 1978, where exogenous mRNA was delivered into host cells using liposomes (1, 2). More recently, cationic lipids, ionizable lipids, among other types of lipids were employed in various LNP formulations for nucleic acid delivery.
The siRNA-LNP drug (Onpattro) was the first LNP formulation to achieve a significant regulatory milestone by gaining FDA approval for the treatment of polyneuropathy (3). This was followed by a paradigmatic shift in the use of these formulations after the significant success these platforms achieved in the development of vaccines against the novel SARS-CoV-2 virus that causes COVID19 .
Prorenata Biotech has optimised formulation techniques to formulate similar LNPs to all approved formulations with superior characteristics and consistency. Get in touch with us if you would like to discuss how you can test these formulations for your genomic medicine.
Prorenata Biotech in the Novel Space of Lipid Nanoparticles
Paving your pathway to the clinics
We are establishing a state-of-the-art GMP facility to streamline the process of moving your therapeutics to the clinics. We aim to provide you with the necessary tools to help you every step of the way. With our years of experience, we will be there to guide you and make sure your project is a success.
Custom and novel formulations
We understand that each therapeutic is different and requires a unique approach. That’s why we offer custom and novel formulations for our Lipid Nanoparticles. Whether you are developing vaccines, anticancer agents, or your application requires improved organ targeting, you’ve come to the right place. Our team of experts are on hand to provide support every step of the way.
Molecular biology to drug delivery
We provide end-to-end services and modular solutions to support your project each step of the way. We will help you along the journey of developing your therapeutics and vaccines, starting from the early stages of discovery, conceptualization and construct designing, through to testing and validation, and all the way to the development of scalable platforms ready for clinical trials. We are experts in gene regulation, molecular biology, and drug delivery platforms. Talk to us today to discuss how we can make your project a success.